Hydroxypropyl MethylCellulose Acetate Succinate
SidleyCel® Hydroxypropyl Methyl Cellulose Acetate Succinate (HPMCAS)
SidleyCel® Hydroxypropyl Methyl Cellulose Acetate Succinate (HPMCAS) is mixed ester of HPMC acetate and succinic acid. It is tasteless, white to light yellow powder or granule, and mainly used for enteric coating.
Characteristics
Cas No. 71138-97-1
As enteric coating material, it has good film-forming property without plasticizer, good solubility in the upper part of small intestine (duodenum), thus can increase medicine absorption in small intestine.
It can be well dissolved in acetone, ethanol- dichloromethane, acetone- ethanol- water and other solvents.
Comply with USP33
| ITEM | Specification |
| Viscosity (mPa.s) | 2.4-3.6 |
| Methoxy (wt, %) | 12-28 |
| Free acetic (wt, %) | 27.0-35.0 |
| Hydroxypropoxy (wt, %) | 4-23 |
| Loss on drying (%) | ≤5.0 |
| Residue on ignition (%) | ≤0.20 |
| Heavy metals (ppm) | ≤10 |
| Content | LG | MG | HG |
| Acetyl group | 5.0-9.0 | 7-11 | 10-14 |
| Butyl two acyl group | 14-18 | 10-14 | 4-8 |
PACKAGING: 10KG/barrel or 25KG/barrel lined with inner PE bag.
Manual for SidleyCel® Cellulose Ethers- TDS-HPMC-AS