Ethyl Cellulose

Ethyl Cellulose did not dissolve in water, but soluble in many organic solvents were used as tablets, granules of the adhesive, can increase the hardness of tablets to reduce friability tablets, it can be used as film-forming agent to improve the appearance of tablets, isolated taste, to avoid the failure of water-sensitive drugs to prevent the influx of metamorphic change agents, promoting the safe storage of tablets, but also can be used as reinforcing material for Sustained Release Tablets.

Technical specification

Comply with USP, EP and CP.

Item K grade N grade
Ethoxy (WT%) 45.5-46.8 47.5-49.5
Viscosity (mPa.s) (5% solu., 20℃) 4, 5, 7, 10, 20, 50, 70, 100, 150, 200, 300
Loss on drying (%) ≤3.0
Residue on ignition (%) ≤0.4
Chloride (%) <0.1
Heavy metals (ppm) ≤20
Arsenic (ppm) ≤3

 

Applications
Pharmaceuticals

Ethyl Cellulose can be used as film former, binder, dispersing agent, stabilizer, water retention agent and controlled release agent in many kinds of medicine.

Coating

Ethyl Cellulose can make up some printing and coating, the coating films have good glossiness and excellent slickening capability and flexibility.

Plastic

Ethyl Cellulose can make up the plastic powder which is easy to take shape, improve cold-resistant property and so on.

In other industry

Ethyl Cellulose is used as temporary coating for fluorescent lamp tube, to raise the viscosity of phosphor and harden the glasses’ surface. In addition, it is used in electricity conductive printing ink which is used in the basement flake in integrated circuit.

Dissolving

The usually used solvents of Ethyl Cellulose(DS:2.3-2.6) are aromatics and alcohols. The aromatics are benzene, toluene, ethylbenzene and xylene, suitable percent:60%-80%. The alcohols are methanol and ethanol etc. suitable ercent: 20-40%.

Ethyl Cellulose is slowly added to the vessel with organic solvent while stirrung, until it is completely wet and dissolved.

Ethyl Cellulose pharmaceutical Application Guide

Ethyl Cellulose because it did not dissolve in water, but soluble in many organic solvents were used as tablets, granules of the adhesive, can increase the hardness of tablets to reduce friability tablets, it can be used as film-forming agent to improve the appearance of tablets, isolated taste, to avoid the failure of water-sensitive drugs to prevent the influx of metamorphic change agents, promoting the safe storage of tablets, but also can be used as reinforcing material for Sustained Release Tablets.

Application suggestion

Specification Reference usage Applications
N-7,N-10,N-20 3-20% Sustained-release coating, to provide a good diffusion membrane and can also adjust the mix of water-soluble HPMC proliferation rate.
N-20,N-50,N-100 10-20% Microcapsules
N-7,N-10,N-20 1-5% Floating layer tablets, used as an organic solvent to form a solid coating with good adhesive film, a masking role of Smell. Often mixed with HPMC.
N-10,N-20 2-6% Tablet granulation binder, used as a solvent for water-sensitive drug granulation, the production has a good dissolution properties of solid tablets. The thermoplastic extrusion granulation help.
 Organic solvent method of solubility and dissolution

Ethyl Cellulose can be dissolved in various organic solvents, such as ethanol, isopropyl alcohol, other alcohols, ketones, aromatic and so on. Common solvent (volume ratio):

*Toluene: Ethanol = 4:1

*Ethanol

*Acetone: Isopropanol = 65:35

*Toluene: Isopropanol = 4:1

*Methyl Acetate: Methanol = 85:15

Alcohols and aromatics in the viscosity of the mixture, going down with alcohol content higher, when alcohol accounts for 30-35%, the lowest viscosity of the composition. Dissolution method: the Ethyl Cellulose under the stirring slowly add the container filled with a solvent until complete wetting dissolved.

Ethyl Cellulose Industrial Application Guide

Ethyl Cellulose provides excellent functionality in many industrial applications. It offers an attractive range of physical properties and can be blended with other materials to achieve intermediate characteristics.

Ethyl Cellulose is widely used in a variety of paints, surface coatings such as metal, paper products, paints, rubber coating, hot melt coating and integrated circuit; for the ink, such as magnetic ink, gravure and flexographic printing inks; for cold material ; for the specialty plastics and special deposits, such as rocket propellant coated with; for insulation and cable coatings; for suspension polymerization of polymer dispersant; for carbide and ceramic adhesives; for the textile industry for printing paste and so on.

Applications

 Specification  Applications
EC N-150, EC N-200  Conductive pastes
EC N-50, EC N-100  Hot melts
EC N-7, EC N-10  Paper coatings
EC N-7, EC N-10, EC N-20  Printing inks
EC N-200  Adhesives
EC N-50  Fluorescent lighting